Cells, Body Fluids, and Transport Practice Questions
76 multiple-choice questions on Cells, body fluids, and transport for paramedic and EMT students, from Chapter 8 (Anatomy and Physiology). Read each question, pick your answer, then tap Show answer to check it and read the explanation.
76 practice questions
Which structure contains the cell's genetic material (DNA)?
- A. Mitochondria
- B. Golgi apparatus
- C. Nucleus
- D. Lysosome
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Answer: C. Nucleus
The nucleus holds the DNA and directs cell activity.
Which organelle produces most of the cell's ATP through aerobic metabolism?
- A. Mitochondria
- B. Golgi apparatus
- C. Lysosome
- D. Ribosome
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Answer: A. Mitochondria
Mitochondria are the cell's powerhouse and need oxygen to make ATP efficiently.
Ribosomes are responsible for making:
- A. Stored glycogen
- B. Proteins
- C. Bile salts
- D. Phospholipids
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Answer: B. Proteins
Ribosomes assemble proteins from amino acids.
Which organelle contains digestive enzymes that break down waste and debris?
- A. Nucleolus
- B. Centriole
- C. Lysosome
- D. Ribosome
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Answer: C. Lysosome
Lysosomes digest worn-out cell parts and foreign material.
The cell membrane is primarily made of a:
- A. Phospholipid bilayer
- B. Carbohydrate matrix
- C. Single protein layer
- D. Cellulose wall
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Answer: A. Phospholipid bilayer
A phospholipid bilayer with embedded proteins makes the membrane selectively permeable.
Mitosis produces:
- A. One larger cell
- B. A cell with half the chromosomes
- C. Four sex cells
- D. Two identical daughter cells
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Answer: D. Two identical daughter cells
Mitosis is ordinary cell division for growth and repair. Meiosis produces sex cells (gametes).
A chemical signal released by a cell that acts on nearby cells is called:
- A. Autocrine
- B. Paracrine
- C. Endocrine
- D. Exocrine
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Answer: B. Paracrine
Paracrine signals act locally, autocrine signals act on the same cell, and endocrine signals travel through the blood.
Aerobic metabolism of one glucose molecule yields roughly how many ATP?
- A. 36-38
- B. 90-100
- C. 12-14
- D. 2-4
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Answer: A. 36-38
Aerobic metabolism yields about 36-38 ATP. Anaerobic metabolism yields only 2.
When cells lack oxygen and switch to anaerobic metabolism, what builds up?
- A. Lactic acid
- B. Carbon dioxide only
- C. Bicarbonate
- D. Glucose
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Answer: A. Lactic acid
Lactic acid builds up and causes metabolic acidosis. This is a hallmark of shock.
Approximately what percentage of an adult's body weight is water?
- A. 45%
- B. 60%
- C. 80%
- D. 30%
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Answer: B. 60%
About 60% of adult body weight is water. Infants have a higher percentage and older adults a lower one.
Most of the body's water is located in which compartment?
- A. Intracellular
- B. Intravascular
- C. Transcellular
- D. Interstitial
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Answer: A. Intracellular
About two-thirds of body water is intracellular. The remaining third is extracellular (interstitial plus intravascular).
Interstitial fluid is the fluid found:
- A. Between the cells
- B. Around the brain and spinal cord
- C. Inside the cells
- D. Inside the blood vessels
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Answer: A. Between the cells
Interstitial fluid bathes the cells outside the vessels. Intravascular fluid is plasma.
Diffusion is the movement of:
- A. Molecules against a gradient using ATP
- B. Fluid pushed across a membrane by pressure
- C. Solutes from high to low concentration
- D. Water toward higher solute concentration
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Answer: C. Solutes from high to low concentration
Diffusion is passive and runs down the concentration gradient. Oxygen moving into tissues is an example.
Osmosis is the movement of:
- A. Water toward higher solute concentration
- B. Fluid pushed out of capillaries by pressure
- C. Molecules against a gradient using ATP
- D. Solutes from high to low concentration
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Answer: A. Water toward higher solute concentration
Water follows solute. This is why IV fluid tonicity matters. Water crosses a semipermeable membrane toward the higher solute concentration.
Facilitated diffusion:
- A. Moves solutes against a gradient
- B. Uses carriers without ATP
- C. Requires ATP to move solutes
- D. Moves only water through channels
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Answer: B. Uses carriers without ATP
A carrier protein helps molecules like glucose cross down their gradient, with no energy used.
The sodium-potassium pump is an example of:
- A. Osmosis
- B. Facilitated diffusion
- C. Simple diffusion
- D. Active transport
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Answer: D. Active transport
It uses ATP to move 3 Na+ out and 2 K+ in, against their gradients.
Filtration across a capillary wall is driven mainly by:
- A. Osmosis across the wall
- B. Active transport pumps
- C. Plasma oncotic pressure
- D. Hydrostatic pressure
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Answer: D. Hydrostatic pressure
Hydrostatic (blood) pressure pushes fluid out of the capillary.
A patient with liver failure and a very low albumin level develops edema and ascites. The main reason is:
- A. High plasma oncotic pressure pulls fluid into tissue
- B. Low plasma oncotic pressure lets fluid leak out of capillaries
- C. Excess platelets block the lymphatic vessels
- D. Raised hemoglobin increases blood viscosity
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Answer: B. Low plasma oncotic pressure lets fluid leak out of capillaries
Albumin, made by the liver, creates most of the plasma oncotic pressure that holds water inside capillaries. When albumin falls, hydrostatic pressure pushes fluid out unopposed, causing edema and ascites. High oncotic pressure would pull fluid in. Platelets and hemoglobin do not set capillary fluid balance.
An IV solution with the same osmolarity as plasma is:
- A. Hypertonic
- B. Hypotonic
- C. Isotonic
- D. A colloid
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Answer: C. Isotonic
Normal saline and lactated Ringer's are isotonic, so they stay in the extracellular space.
A red blood cell placed in a hypotonic solution will:
- A. Remain unchanged in size
- B. Lose water and collapse
- C. Shrink and crenate
- D. Swell and possibly burst
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Answer: D. Swell and possibly burst
Water moves into the cell, where the solute concentration is higher.
A cell placed in a hypertonic solution will:
- A. Swell as water enters it
- B. Burst from water gain
- C. Shrink and crenate
- D. Stay about the same size
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Answer: C. Shrink and crenate
Water leaves the cell toward the higher solute concentration outside, so the cell shrinks (crenates).
The cell membrane's primary function is to:
- A. Digest waste and debris
- B. Produce energy for the cell
- C. Store the genetic material
- D. Control what enters and leaves
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Answer: D. Control what enters and leaves
It is described as selectively permeable.
Proteins embedded in the cell membrane may act as:
- A. Energy stores for the cell
- B. Channels, receptors, and pumps
- C. Digestive enzymes for waste
- D. Genetic material carriers
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Answer: B. Channels, receptors, and pumps
They allow specific substances to cross.
Cytoplasm refers to:
- A. The outer cell membrane
- B. Fluid outside of the cell
- C. The nucleus and its contents
- D. Gel-like fluid holding organelles
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Answer: D. Gel-like fluid holding organelles
Most cellular chemistry happens here.
The endoplasmic reticulum functions in:
- A. ATP production by oxidation
- B. Digesting worn-out organelles
- C. Cell division and DNA copying
- D. Protein and lipid synthesis
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Answer: D. Protein and lipid synthesis
Rough ER carries ribosomes; smooth ER makes lipids. It synthesizes and transports proteins and lipids.
The Golgi apparatus is responsible for:
- A. Producing ATP from glucose
- B. Packaging proteins for export
- C. Digesting engulfed bacteria
- D. Copying DNA before division
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Answer: B. Packaging proteins for export
Think of it as the cell's shipping department. It modifies and packages proteins for transport.
During cardiac arrest, myocardial cells run out of ATP within minutes mainly because which organelle cannot work without oxygen?
- A. Ribosomes
- B. Mitochondria
- C. Lysosomes
- D. Golgi apparatus
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Answer: B. Mitochondria
Mitochondria make most ATP by aerobic metabolism, which stops without oxygen. Cells with high energy demand, such as heart and brain cells, are packed with mitochondria and fail first. Ribosomes make proteins, lysosomes digest waste, and the Golgi packages proteins; none of these is the main energy source.
The nucleolus is responsible for:
- A. Producing ATP for the cell
- B. Digesting cellular waste
- C. Storing calcium ions
- D. Producing ribosomes
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Answer: D. Producing ribosomes
It sits inside the nucleus.
Cellular respiration requires which two inputs?
- A. Glucose and oxygen
- B. Carbon dioxide and water
- C. Protein and fat
- D. Water and salt
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Answer: A. Glucose and oxygen
It produces ATP, carbon dioxide, and water.
The waste products of aerobic metabolism are:
- A. Lactic acid and heat
- B. Glucose and oxygen
- C. CO2 and water
- D. Ketones and ammonia
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Answer: C. CO2 and water
The lungs and kidneys remove them.
Anaerobic metabolism is inefficient because it:
- A. Cannot use glucose as fuel
- B. Produces too much carbon dioxide
- C. Yields only 2 ATP per glucose
- D. Uses more oxygen per glucose
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Answer: C. Yields only 2 ATP per glucose
It also generates lactic acid.
The number of chromosomes in a normal human somatic cell is:
- A. 92
- B. 23
- C. 46
- D. 12
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Answer: C. 46
Sex cells contain 23.
Meiosis produces:
- A. Two identical daughter cells
- B. Four identical body cells
- C. Gametes with 23 chromosomes
- D. Cells with double the chromosomes
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Answer: C. Gametes with 23 chromosomes
Fertilization restores the full number. Sex cells have half the normal chromosome number.
Cellular differentiation refers to:
- A. Programmed cell death
- B. Cells swelling from water gain
- C. Cells dividing at random
- D. Cells specializing for functions
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Answer: D. Cells specializing for functions
It is how one fertilized egg produces many cell types.
Mitosis is important for:
- A. Producing sex cells
- B. Tissue growth and repair
- C. Transporting oxygen
- D. Breaking down glucose
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Answer: B. Tissue growth and repair
Damaged tissue repairs through it.
Passive transport processes:
- A. Require ATP to proceed
- B. Move solutes against gradients
- C. Occur only in muscle cells
- D. Need no cellular energy
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Answer: D. Need no cellular energy
Diffusion, osmosis, and filtration are passive.
Active transport is necessary when a substance must:
- A. Move down its gradient
- B. Move against its gradient
- C. Cross the membrane freely
- D. Dissolve in water
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Answer: B. Move against its gradient
The sodium-potassium pump is the classic example.
The sodium-potassium pump moves:
- A. Equal sodium and potassium
- B. 3 sodium out, 2 potassium in
- C. 3 sodium in, 2 potassium out
- D. 2 sodium out, 3 potassium in
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Answer: B. 3 sodium out, 2 potassium in
This creates the resting membrane potential.
Failure of the sodium-potassium pump during hypoxia causes:
- A. Cell swelling from sodium influx
- B. Cell shrinkage from water loss
- C. Potassium to build up inside
- D. Increased ATP production in cells
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Answer: A. Cell swelling from sodium influx
Cellular swelling is an early sign of injury. Sodium and water move into the cell.
Endocytosis refers to:
- A. Division of one cell into two
- B. Water moving across membranes
- C. Releasing material from the cell
- D. Engulfing material into the cell
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Answer: D. Engulfing material into the cell
Phagocytosis is one form of it.
Exocytosis refers to:
- A. Programmed death of the cell
- B. Taking material into the cell
- C. Passive diffusion of solutes
- D. Releasing material via vesicles
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Answer: D. Releasing material via vesicles
Hormone and neurotransmitter release use it.
Phagocytosis is performed primarily by:
- A. White blood cells
- B. Plasma proteins
- C. Mature red blood cells
- D. Circulating platelets
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Answer: A. White blood cells
It is a key part of innate immunity. Neutrophils and macrophages engulf pathogens and debris.
A patient with left-sided heart failure develops pulmonary edema mainly because:
- A. Plasma oncotic pressure in the pulmonary capillaries rises
- B. Lymphatic drainage from the lungs increases sharply
- C. Surfactant production in the alveoli increases
- D. Raised capillary hydrostatic pressure pushes fluid into the lungs
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Answer: D. Raised capillary hydrostatic pressure pushes fluid into the lungs
When the left ventricle fails, pressure backs up into the pulmonary veins and capillaries. Higher hydrostatic pressure pushes fluid out into the interstitium and alveoli. A rise in oncotic pressure would pull fluid back in. More lymph drainage and more surfactant would both work against edema.
Edema develops when:
- A. Interstitial fluid accumulates
- B. Intracellular water decreases
- C. Cells shrink from water loss
- D. Oncotic pressure exceeds hydrostatic
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Answer: A. Interstitial fluid accumulates
Heart failure and low albumin are common causes.
Extracellular fluid includes:
- A. Interstitial fluid and plasma
- B. Plasma only
- C. Cerebrospinal fluid only
- D. Intracellular fluid and plasma
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Answer: A. Interstitial fluid and plasma
It makes up about one-third of body water.
The intravascular compartment contains approximately what portion of total body water?
- A. Half of total body water
- B. Two-thirds of total body water
- C. About 25% of body weight
- D. Plasma, about 5% of body weight
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Answer: D. Plasma, about 5% of body weight
Plasma volume is small but critical.
Infants have a higher percentage of body water than adults, which means they:
- A. Need less fluid per kg
- B. Tolerate fluid loss better
- C. Have more body fat per kg
- D. Dehydrate more quickly
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Answer: D. Dehydrate more quickly
Fluid losses are proportionally larger. Vomiting and diarrhea cause proportionally larger losses.
Older adults typically have:
- A. The same water as infants
- B. Less total body water
- C. More total body water
- D. Faster thirst responses
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Answer: B. Less total body water
Reduced thirst sensation compounds the risk. This increases dehydration risk.
In the hospital, hypertonic saline is given to reduce brain swelling. How does it work?
- A. It moves water into cells to stabilize them
- B. It draws water out of brain cells into the blood
- C. It dilates cerebral vessels to drain fluid
- D. It lowers blood sodium to reduce edema
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Answer: B. It draws water out of brain cells into the blood
A hypertonic solution raises plasma osmolarity, so water moves by osmosis out of cells, including swollen brain cells, into the vascular space. Moving water into cells would worsen edema. It does not act by dilating vessels, and it raises blood sodium rather than lowering it.
The blood-brain barrier is formed by:
- A. Fenestrated capillaries
- B. The pia and arachnoid mater
- C. Tight capillary junctions
- D. The skull and dura mater
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Answer: C. Tight capillary junctions
It limits which substances reach brain tissue. Tight junctions between brain capillary cells form the barrier.
Diffusion occurs faster when:
- A. The membrane is thick
- B. Temperature is low
- C. The gradient is steep
- D. The gradient is small
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Answer: C. The gradient is steep
These principles govern gas exchange in the alveoli. A short distance and large surface area also speed it.
Facilitated diffusion is required for substances that:
- A. Move against gradients
- B. Are lipid soluble
- C. Need ATP to move
- D. Are too large or polar
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Answer: D. Are too large or polar
Glucose transport uses carrier proteins.
Filtration in the body is best illustrated by:
- A. Gas exchange in alveoli
- B. Glucose uptake into muscle cells
- C. Water absorption in the colon
- D. The kidney glomerulus
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Answer: D. The kidney glomerulus
Pressure forces fluid across a membrane. In the glomerulus, blood pressure pushes water and small solutes out of the capillaries into the capsule. Glucose enters muscle cells by facilitated diffusion through carrier proteins, water is absorbed in the colon by osmosis, and alveolar gas exchange is diffusion; none of these is pressure-driven filtration.
A shocked patient's cells switch to anaerobic metabolism. What is the main consequence for cellular energy?
- A. More ATP is produced, along with extra lactic acid
- B. The same amount of ATP is produced from less glucose
- C. Far less ATP per glucose, so membrane pumps begin to fail
- D. ATP production stops completely within seconds
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Answer: C. Far less ATP per glucose, so membrane pumps begin to fail
Anaerobic glycolysis yields only 2 ATP per glucose, far less than aerobic metabolism (about 30 or more). Energy-hungry processes such as the sodium-potassium pump start to fail, so cells swell, and lactic acid builds up. ATP production falls sharply but does not stop.
Which condition results directly from prolonged anaerobic metabolism?
- A. Metabolic acidosis
- B. Hypernatremia
- C. Metabolic alkalosis
- D. Respiratory alkalosis
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Answer: A. Metabolic acidosis
Lactic acid accumulates in the blood.
The resting membrane potential of a cell is maintained by:
- A. Sodium-potassium pump activity
- B. Passive leakage of chloride
- C. Capillary hydrostatic pressure
- D. Osmosis of water into cells
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Answer: A. Sodium-potassium pump activity
It makes nerve and muscle excitability possible. The pump keeps sodium and potassium unequally distributed by active transport.
Cell membranes are described as selectively permeable because they:
- A. Let only water and gases pass
- B. Sort particles by size alone
- C. Pass substances in one direction
- D. Let some pass and block others
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Answer: D. Let some pass and block others
This maintains the internal environment. Permeability depends on size, charge, lipid solubility, and the channels and carriers present, not size alone. Substances cross the membrane in both directions, entering and leaving as needed.
A cell deprived of oxygen will first show:
- A. Increased protein synthesis
- B. Reversible cell swelling
- C. Increased cell division
- D. Immediate cell death
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Answer: B. Reversible cell swelling
Restoring oxygen early can reverse them. Early changes include swelling and reduced ATP.
Reperfusion injury occurs when:
- A. Oxygen is withheld too long
- B. Cells divide after ischemia
- C. Blood flow is first blocked
- D. Restored flow causes damage
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Answer: D. Restored flow causes damage
It complicates resuscitation from ischemia. Restored blood flow generates free radicals and inflammation that further damage tissue.
Which statement about cellular oxygen use is accurate?
- A. Cells store large oxygen reserves
- B. Anaerobic metabolism meets full demand
- C. Cells need constant oxygen supply
- D. Brain cells tolerate hypoxia longest
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Answer: C. Cells need constant oxygen supply
This is why perfusion interruption harms so quickly. Cells hold almost no oxygen in reserve. Anaerobic metabolism yields only a small fraction of the ATP of aerobic metabolism, so it cannot meet normal demand. Brain cells are among the least tolerant of hypoxia and are injured within minutes.
A 70-kg adult has about 42 L of total body water. About how much of it is inside the cells?
- A. 14 L
- B. 3 L
- C. 28 L
- D. 42 L
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Answer: C. 28 L
About two-thirds of body water is intracellular: 28 of 42 L. The remaining one-third (14 L) is extracellular, and about 3 L of that is plasma. This is why a liter of crystalloid spreads mostly into the interstitial space rather than staying in the vessels.
Which organ system has the greatest role in regulating body fluid volume?
- A. Integumentary
- B. Respiratory
- C. Digestive
- D. Urinary
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Answer: D. Urinary
The kidneys adjust water and sodium excretion.
Insensible water loss occurs through:
- A. Vomiting and diarrhea
- B. Skin and exhaled air
- C. Urine and stool output
- D. Visible sweating only
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Answer: B. Skin and exhaled air
It increases with fever and rapid breathing.
Which hormone directly controls water reabsorption by the kidneys?
- A. Aldosterone
- B. Cortisol
- C. Antidiuretic hormone
- D. Atrial natriuretic peptide
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Answer: C. Antidiuretic hormone
It is released from the posterior pituitary.
Which hormone controls sodium retention?
- A. Calcitonin
- B. Glucagon
- C. Aldosterone
- D. Antidiuretic hormone
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Answer: C. Aldosterone
Water follows the retained sodium.
A patient with severe vomiting is likely to lose which electrolytes?
- A. Sodium and bicarbonate
- B. Calcium and magnesium only
- C. Acid, chloride, and potassium
- D. Bicarbonate and potassium
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Answer: C. Acid, chloride, and potassium
Metabolic alkalosis may result. Hydrogen ions, chloride, and potassium are lost, along with some sodium.
Excessive diarrhea most often produces:
- A. Respiratory acidosis
- B. No acid-base change
- C. Metabolic acidosis
- D. Metabolic alkalosis
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Answer: C. Metabolic acidosis
Potassium is also lost. Bicarbonate is lost in the stool.
The osmotic effect of glucose in the bloodstream during hyperglycemia causes:
- A. Water drawn into cells
- B. No significant fluid shift
- C. Osmotic diuresis
- D. Cells swelling with water
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Answer: C. Osmotic diuresis
This produces the dehydration seen in DKA. Glucose pulls water into the vascular space and it is lost in the urine.
Which best describes plasma?
- A. Serum left after clotting
- B. The fluid portion of blood
- C. Lymph from the tissues
- D. The cellular part of blood
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Answer: B. The fluid portion of blood
It makes up roughly 55 percent of blood volume. Plasma is straw-colored and contains water, proteins, and electrolytes.
Albumin's most important function in fluid balance is to:
- A. Transporting oxygen to tissues
- B. Forming fibrin blood clots
- C. Maintaining oncotic pressure
- D. Buffering blood pH
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Answer: C. Maintaining oncotic pressure
Low albumin produces widespread edema.
Third spacing describes fluid that has:
- A. Remained within the vascular space
- B. Shifted back into the cells
- C. Been excreted by the kidneys
- D. Become unavailable to circulation
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Answer: D. Become unavailable to circulation
Burns and sepsis produce it.
Which finding suggests significant intravascular fluid loss?
- A. Bradycardia and flushing
- B. Hypertension and edema
- C. Tachycardia and dry mucosa
- D. Bounding pulse and warm skin
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Answer: C. Tachycardia and dry mucosa
Orthostatic changes may appear early. Poor skin turgor is another sign.
The cell's genetic instructions are carried out through:
- A. Lysosomes copying the genes
- B. RNA messages to ribosomes
- C. DNA acting directly in cytoplasm
- D. Mitochondria reading DNA
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Answer: B. RNA messages to ribosomes
Proteins built there determine cell function.
Cellular adaptation to increased workload commonly results in:
- A. Necrosis
- B. Hypertrophy
- C. Atrophy
- D. Apoptosis
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Answer: B. Hypertrophy
The heart enlarges under chronic pressure load.
A cell that is no longer stimulated or used tends to undergo:
- A. Atrophy
- B. Hyperplasia
- C. Metaplasia
- D. Hypertrophy
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Answer: A. Atrophy
Immobilized muscle shrinks quickly.
Which statement about apoptosis is correct?
- A. It occurs only with disease
- B. It requires no cellular energy
- C. It triggers local inflammation
- D. It is programmed cell death
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Answer: D. It is programmed cell death
Necrosis, in contrast, damages neighboring tissue. It is a normal process for removing unneeded cells.
More Anatomy and Physiology practice questions
- Levels of organization and chemistry (74)
- Cells, body fluids, and transport
- Tissues, membranes, and homeostasis (42)
- Integumentary system (36)
- Skeletal system (87)
- Muscular system (50)
- Nervous system (109)
- Endocrine system (64)
- Blood (54)
- The heart (81)
- Blood vessels and the lymphatic system (54)
- Respiratory system (105)
- Digestive system and abdomen (63)
- Urinary system and fluid balance (50)
- Reproductive system (37)
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